The Administrator > QuickBooks Connection is to map the QuickBooks file to the Corporate Division in e-manage|ONE. You can also locate this setting from Tools > Configure > User Settings. In e-manage One you can have run multiple companies and each company will be associated with its own set of financials. e-manage|ONE allows you to view each company individually and combined without affecting the financials. You only need to map the QB file location on one user's machine and it will apply to every user.
Configure QuickBooks Data File
Note: Your QuickBooks data file should not be located on your Desktop